Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: The study was supported by grants (PI16/01404 and PI16/01395), the Spanish Network for Addictive Disorders (Red de Trastornos Adictivos, RD16/0017/0018), the Spanish Network for Preventive Activity & Health Promotion Research in Primary Care (Red de Actividades Preventivas y de Promocion de Salud en Atención Primaria, RD16/0007/0006), and a personal grant (awarded to IC, Rio-Hortega Grant CM17/00113, Funder Id: http://dx.doi.org/10.13039/501100004587) from the Carlos III Institute of Health (Instituto de Salud Carlos III [ISCIII], Spanish Ministry of Health), in all cases with cofunding from FEDER (Fondo Europeo de Desarrollo Regional) funds. Genotyping was carried out at CEGEN-PRB3-ISCIII, supported by grant PT17/0019, of the PE I+D+i 2013-2016, funded by ISCIII and FEDER. A personal grant (Funder Id: http://dx.doi.org/10.13039/100014440, SIA-998142) was also awarded to MD by the Spanish Ministry of Science, Innovation and Universities.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization (s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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