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Licensed Unlicensed Requires Authentication Published by De Gruyter April 18, 2020

The clinically effective use of cardiac markers by restructuring laboratory profiles at Cardiology wards

  • Martin H. Keppel ORCID logo , Tobias Kolbitsch ORCID logo , Uta C. Hoppe , Simon Auer , Thomas K. Felder ORCID logo , Hannes Oberkofler , Cornelia Mrazek , Elisabeth Haschke-Becher and Janne Cadamuro ORCID logo EMAIL logo

Abstract

Background

Laboratory overutilization is associated with diagnostic error and potential patient risk. We applied a demand management strategy in collaboration with the local Department of Cardiology to reduce the cardiac markers high-sensitive troponin T (hsTropT) and N-terminal pro brain natriuretic peptide (NTproBNP) in laboratory ordering profiles (LOPs). The present study aimed to retrospectively evaluate the implemented strategies.

Methods

Strategies included educational measures and evidence-guided, active test de-selection from all cardiology ward LOPs, and/or permanent removal from LOPs. Tests remained available at all times. We evaluated overutilization by reductions in monthly orders, and assessed differences in 30-day all-cause readmission rate and length of patients’ hospital stay.

Results

Overall, we observed a mean reduction of 66.1% ± 7.6% (n = 277 ± 31) in hsTropT tests. Educational measures effectively reduced NTproBNP orders by 52.8% ± 17.7% (n = 60 ± 20). Permanent removal of tests from LOPs additionally decreased orders to a final extent of 75.8% ± 8.0% (n = 322 ± 31) in NTproBNP tests. The 30-day readmission rate and overall length of hospital stay did not increase.

Conclusions

Our results indicate that cardiac markers in routine care are subject to extensive overutilization when used within LOPs. Educational measures are an effective strategy to overcome the overutilization of cardiac markers but may be more effective when combined with the removal of cardiac markers from LOPs.


Corresponding author: Janne Cadamuro, MD, Department of Laboratory Medicine, Paracelsus Medical University, Müllner Hauptstr. 48, 5020 Salzburg, Austria, Phone: +43 (0)5 7255 57263, Fax: +43 (0)5 7255 23199

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

1. Wilkins E, Wilson L, Wickramasinghe K, Bhatnagar P, Leal J, Luengo-Fernandez R, et al. European Cardiovascular Disease Statistics 2017. Brussels: European Heart Network, 2017.Search in Google Scholar

2. Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol 2014;63:1123–33.10.1016/j.jacc.2013.11.053Search in Google Scholar PubMed

3. Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J 2019;40:237–69.10.1093/eurheartj/ehy462Search in Google Scholar PubMed

4. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016;37:2129–200.10.1002/ejhf.592Search in Google Scholar PubMed

5. Campbell AR, Rodriguez AJ, Larson DM, Strauss CE, Garberich RF, Partridge MF, et al. Resource utilization and outcome amongpatients with selective versus nonselective troponin testing. Am Heart J 2018;199:68–74.10.1016/j.ahj.2018.01.010Search in Google Scholar PubMed

6. Gaggin HK, Januzzi Jr. JL. The past, the present, and the future of natriuretic peptides in the diagnosis of heart failure. Eur Heart J Suppl 2018;20(suppl_G):G11–20.10.1093/eurheartj/suy024Search in Google Scholar

7. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey Jr. DE, Colvin MM, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation 2017;136:e137–61.10.1161/CIR.0000000000000509Search in Google Scholar PubMed

8. Shah MR, Califf RM, Nohria A, Bhapkar M, Bowers M, Mancini DM, et al. The STARBRITE trial: a randomized, pilot study of B-type natriuretic peptide-guided therapy in patients with advanced heart failure. J Card Fail 2011;17:613–21.10.1016/j.cardfail.2011.04.012Search in Google Scholar PubMed

9. Thygesen K, Mair J, Mueller C, Huber K, Weber M, Plebani M, et al. Recommendations for the use of natriuretic peptides in acute cardiac care: a position statement from the Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care. Eur Heart J 2012;33:2001–6.10.1093/eurheartj/ehq509Search in Google Scholar PubMed

10. Cadamuro J, Ibarz M, Cornes M, Nybo M, Haschke-Becher E, von Meyer A, et al. Managing inappropriate utilization of laboratory resources. Diagnosis (Berl) 2019;6:5–13.10.1515/dx-2018-0029Search in Google Scholar PubMed

11. Aarsand AK, Sandberg S. How to achieve harmonisation of laboratory testing – the complete picture. Clin Chim Acta 2014;432:8–14.10.1016/j.cca.2013.12.005Search in Google Scholar PubMed

12. Freedman DB. Towards better test utilization - strategies to improve physician ordering and their impact on patient outcomes. EJIFCC 2015;26:15–30.Search in Google Scholar

13. Epner PL, Gans JE, Graber ML. When diagnostic testing leads to harm: a new outcomes-based approach for laboratory medicine. BMJ Qual Saf 2013;22(Suppl 2):ii6–10.10.1136/bmjqs-2012-001621Search in Google Scholar PubMed PubMed Central

14. Hawkins R. Managing the pre- and post-analytical phases of the total testing process. Ann Lab Med 2012;32:5–16.10.3343/alm.2012.32.1.5Search in Google Scholar PubMed PubMed Central

15. Salinas M, Lopez-Garrigos M, Asencio A, Batlle E, Minguez M, Lugo J, et al. Strategy to improve the request of uric acid in primary care: preliminary results and evaluation through process and outcome appropriateness indicators. Clin Biochem 2014;47:467–70.10.1016/j.clinbiochem.2013.12.025Search in Google Scholar PubMed

16. Arundel C, Lam PH, Khosla R, Blackman MR, Fonarow GC, Morgan C, et al. Association of 30-day all-cause readmission with long-term outcomes in hospitalized older medicare beneficiaries with heart failure. Am J Med 2016;129:1178–84.10.1016/j.amjmed.2016.06.018Search in Google Scholar PubMed PubMed Central

17. Benmachiche M, Marques-Vidal P, Waeber G, Mean M. In-hospital mortality is associated with high NT-proBNP level. PLoS One 2018;13:e0207118.10.1371/journal.pone.0207118Search in Google Scholar PubMed PubMed Central

18. Swaminathan RV, Rao SV, McCoy LA, Kim LK, Minutello RM, Wong SC, et al. Hospital length of stay and clinical outcomes in older STEMI patients after primary PCI: a report from the National Cardiovascular Data Registry. J Am Coll Cardiol 2015;65:1161–71.10.1016/j.jacc.2015.01.028Search in Google Scholar PubMed

19. Flint K, Allen L, Pham M, Heidenreich P. B-type natriuretic peptide predicts 30-day readmission for heart failure but not readmission for other causes. J Am Heart Assoc 2014;3:e000806.10.1161/JAHA.114.000806Search in Google Scholar PubMed PubMed Central

20. Tanindi A, Cemri M. Troponin elevation in conditions other than acute coronary syndromes. Vasc Health Risk Manag 2011;7: 597–603.10.2147/VHRM.S24509Search in Google Scholar PubMed PubMed Central

21. Gahl B, Gober V, Odutayo A, Tevaearai Stahel HT, da Costa BR, Jakob SM, et al. Prognostic value of early postoperative troponin T in patients undergoing coronary artery bypass grafting. J Am Heart Assoc 2018;7:5. (pii):JAHA.117.007743.10.1161/JAHA.117.007743Search in Google Scholar PubMed PubMed Central

22. Julicher P, Greenslade JH, Parsonage WA, Cullen L. The organisational value of diagnostic strategies using high-sensitivity troponin for patients with possible acute coronary syndromes: a trial-based cost-effectiveness analysis. BMJ Open 2017;7:e013653.10.1136/bmjopen-2016-013653Search in Google Scholar PubMed PubMed Central

23. Brush Jr. JE, Kaul S, Krumholz HM. Troponin testing for clinicians. J Am Coll Cardiol 2016;68:2365–75.10.1016/j.jacc.2016.08.066Search in Google Scholar PubMed

24. Willeit P, Welsh P, Evans JD, Tschiderer L, Boachie C, Jukema JW, et al. High-sensitivity cardiac troponin concentration and risk of first-ever cardiovascular outcomes in 154,052 participants. J Am Coll Cardiol 2017;70:558–68.10.1016/j.jacc.2017.05.062Search in Google Scholar PubMed PubMed Central

25. Vestergaard KR, Jespersen CB, Arnadottir A, Soletormos G, Schou M, Steffensen R, et al. Prevalence and significance of troponin elevations in patients without acute coronary disease. Int J Cardiol 2016;222:819–25.10.1016/j.ijcard.2016.07.166Search in Google Scholar PubMed

26. Twerenbold R, Boeddinghaus J, Nestelberger T, Wildi K, Rubini Gimenez M, Badertscher P, et al. Clinical use of high-sensitivity cardiac troponin in patients with suspected myocardial infarction. J Am Coll Cardiol 2017;70:996–1012.10.1016/j.jacc.2017.07.718Search in Google Scholar PubMed

27. Gardezi SA. Troponin: think before you request one. BMJ Qual Improv Rep 2015;4.10.1136/bmjquality.u204560.w3221Search in Google Scholar PubMed PubMed Central

28. Kumwilaisak K, Noto A, Schmidt UH, Beck CI, Crimi C, Lewandrowski K, et al. Effect of laboratory testing guidelines on the utilization of tests and order entries in a surgical intensive care unit. Crit Care Med 2008;36:2993–9.10.1097/CCM.0b013e31818b3a9dSearch in Google Scholar PubMed

29. Larochelle MR, Knight AM, Pantle H, Riedel S, Trost JC. Reducing excess cardiac biomarker testing at an academic medical center. J Gen Intern Med 2014;29:1468–74.10.1007/s11606-014-2919-5Search in Google Scholar PubMed PubMed Central

30. Meng QH, Zhu S, Booth C, Stevens L, Bertsch B, Qureshi M, et al. Impact of the cardiac troponin testing algorithm on excessive and inappropriate troponin test requests. Am J Clin Pathol 2006;126:195–9.10.1309/GK9BFAB1Y5LNBWU1Search in Google Scholar

31. McCullough PA, Nowak RM, McCord J, Hollander JE, Herrmann HC, Steg PG, et al. B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly (BNP) Multinational Study. Circulation 2002;106:416–22.10.1161/01.CIR.0000025242.79963.4CSearch in Google Scholar PubMed

32. Moe GW, Howlett J, Januzzi JL, Zowall H. N-terminal pro-B-type natriuretic peptide testing improves the management of patients with suspected acute heart failure: primary results of the Canadian prospective randomized multicenter IMPROVE-CHF study. Circulation 2007;115:3103–10.10.1161/CIRCULATIONAHA.106.666255Search in Google Scholar PubMed

33. Lang T, Croal B. Clinical Practice Group of the Association for Clinical Biochemistry and Laboratory Medicine and supported by the Royal College of Pathologists. National Minimum Re-testing Interval Project: a final report detailing consensus recommendations for minimum re-testing intervals for use in Clinical Biochemistry. London: The Royal College of Pathologists, 2015. Unique document number: G147: https://www.rcpath.org/uploads/assets/253e8950-3721-4aa2-8ddd4bd94f73040e/g147_minretestingintervalsinpathology_dec15.pdf [Accessed 2019-09-02].Search in Google Scholar

34. Levick DL, Stern G, Meyerhoefer CD, Levick A, Pucklavage D. Reducing unnecessary testing in a CPOE system through implementation of a targeted CDS intervention. BMC Med Inform Decis Mak 2013;13:43.10.1186/1472-6947-13-43Search in Google Scholar PubMed PubMed Central

35. Moyer AM, Saenger AK, Willrich M, Donato LJ, Baumann NA, Block DR, et al. Implementation of clinical decision support rules to reduce repeat measurement of serum ionized calcium, serum magnesium, and N-terminal pro-B-type natriuretic peptide in intensive care unit inpatients. Clin Chem 2016;62:824–30.10.1373/clinchem.2015.250514Search in Google Scholar PubMed

36. Miyakis S, Karamanof G, Liontos M, Mountokalakis TD. Factors contributing to inappropriate ordering of tests in an academic medical department and the effect of an educational feedback strategy. Postgrad Med J 2006;82:823–9.10.1136/pgmj.2006.049551Search in Google Scholar PubMed PubMed Central

37. Mindemark M, Larsson A. Long-term effects of an education programme on the optimal use of clinical chemistry testing in primary health care. Scand J Clin Lab Invest 2009;69:481–6.10.1080/00365510902749123Search in Google Scholar PubMed

38. Smellie WS. Demand management and test request rationalization. Ann Clin Biochem 2012;49(Pt 4):323–36.10.1258/acb.2011.011149Search in Google Scholar PubMed

39. Cadamuro J, Gaksch M, Wiedemann H, Lippi G, von Meyer A, Pertersmann A, et al. Are laboratory tests always needed? Frequency and causes of laboratory overuse in a hospital setting. Clin Biochem 2018;54:85–91.10.1016/j.clinbiochem.2018.01.024Search in Google Scholar PubMed

Received: 2019-11-27
Accepted: 2020-03-04
Published Online: 2020-04-18
Published in Print: 2020-08-27

©2020 Walter de Gruyter GmbH, Berlin/Boston

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