Abstract
Objectives
Drug-laboratory test interactions (DLTIs) are one of the major sources of laboratory errors. Calcium dobesilate (CaD) interference on serum creatinine testing is a widespread problem that has long been ignored in China. A national EQA-based survey was launched to investigate the current status of CaD interference on creatinine routine methods used in China and enhance the education of CaD interference in clinical laboratories.
Methods
A descriptive survey was developed to characterize the status quo of Chinese laboratory professionals’ cognition to CaD interference. Four of survey samples which were spiked with/without interference additive were shipped to 175 participant laboratories. The target reference values from a reference measurement procedure were compared against the results from participating laboratories to evaluate the CaD interference on serum creatinine measurements using enzymatic method or Jaffé method.
Results
The lack of knowledge of DLTIs and the barriers to collect information from pharmacological and laboratory data systems had become the main problems on implementing DLTIs education in China. A significant negative influence of CaD on enzymatic method was observed regardless of measurement platforms. Jaffé method was generally free from interaction with CaD but showed poor precision and accuracy at low creatinine concentrations.
Conclusions
More efforts should be made to enhance the education of DLTIs in clinical laboratories in China.
Funding source: China Capital Health Research and Development of Special Project
Award Identifier / Grant number: 2016-2-4017
Research funding: This study was financially supported by the China Capital Health Research and Development of Special Project (2016-2-4017).
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Ethical approval: Anonymized left-over sera were collected from patients receiving physical examinations or hospitalized at Peking Union Medical College Hospital (PUMCH, Beijing, China). The study was reviewed and approved by the Ethics Committee of PUMCH.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/cclm-2020-0424).
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