This article is a brief review on the effects of exercise stress upon the major hormonal components that make up the human neuroendocrine system. The review is organized into four major topics, which are presented and dealt with in the form of questions. These questions are: 1) Is exercise a stressor to the neuroendocrine system? 2) Why would exercise be a stressor to the neuroendocrine system? 3) What are the effects of exercise as a stressor upon the neuroendocrine system? 4) Is exercise always a stressor to the neuroendocrine system? These questions are addressed and answered in the article in an attempt to provide fundamental background knowledge on neuroendocrine response to exercise.