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Licensed Unlicensed Requires Authentication Published by De Gruyter February 23, 2021

Free-thyroxine standardization: waiting for Godot while well serving our patients today

  • Luca Giovanella ORCID logo EMAIL logo
From the journal Clinical Chemistry and Laboratory Medicine (CCLM)
https://doi.org/10.1515/cclm-2021-0201
Keywords: thyroid; thyroid hormones; thyroxine
Corresponding author: Luca Giovanella, MD, PhD, Clinic for Nuclear Medicine and Competence Centre for Thyroid Diseases, Ente Ospedaliero Cantonale, Via A. Gallino 12, 6500 Bellinzona, Switzerland; and University Hospital and University of Zurich, Zurich, Switzerland, Phone: +41 91 811 86 72, Fax: +41 91 811 85 02, E-mail:

  1. Research funding: None declared.

  2. Author contributions: The author has accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The author received research fees, speaker fees and participated in an advisory board of Roche Diagnostics, Rothkreutz, Switzerland.

References

1. Midgley, JE. Global FT4 Immunoassay Standardization. Response to: Kratzsch J et al. Global FT4 immunoassay standardization: an expert opinion review. Clin Chem Lab Med 2021;59:e223–4.10.1515/cclm-2021-0036Search in Google Scholar PubMed

2. Kratzsch, J, Baumann, NA, Ceriotti, F, Lu, ZX, Schott, M, van Herwaarden, AE, et al.. Global FT4 immunoassay standardization: an expert opinion review. Clin Chem Lab Med 2021;59:1013–23. https://doi.org/10.1515/cclm-2020-1696.Search in Google Scholar PubMed

3. Plebani, M, Giovanella, L. Reflex TSH strategy: the good, the bad and the ugly. Clin Chem Lab Med 2019;58:1–2. https://doi.org/10.1515/cclm-2019-0625.Search in Google Scholar PubMed

Received: 2021-02-13
Accepted: 2021-02-15
Published Online: 2021-02-23
Published in Print: 2021-05-26

© 2021 Walter de Gruyter GmbH, Berlin/Boston

From the journal
Clinical Chemistry and Laboratory Medicine (CCLM)
Clinical Chemistry and Laboratory Medicine (CCLM)
Volume 59 Issue 6
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Journal and Issue

Articles in the same Issue

Frontmatter
Editorial
COVID-19: which lessons have we learned?
Review
Global FT4 immunoassay standardization: an expert opinion review
Mini Review
Mechanism of bilirubin elimination in urine: insights and prospects for neonatal jaundice
Opinion Paper
Laboratory medicine in the COVID-19 era: six lessons for the future
EFLM Paper
How to meet ISO15189:2012 pre-analytical requirements in clinical laboratories? A consensus document by the EFLM WG-PRE
General Clinical Chemistry and Laboratory Medicine
External quality assessment of M-protein diagnostics: a realistic impression of the accuracy and precision of M-protein quantification
Error simulation modeling to assess the effects of bias and precision on bilirubin measurements used to screen for neonatal hyperbilirubinemia
NT-proBNP levels in preeclampsia, intrauterine growth restriction as well as in the prediction on an imminent delivery
Serum N-glycan fingerprint nomogram predicts liver fibrosis: a multicenter study
Hematology and Coagulation
Performance of digital morphology analyzer Vision Pro on white blood cell differentials
Cardiovascular Diseases
Prognostic implication of elevated cardiac troponin I in patients visiting emergency department without diagnosis of coronary artery disease
Relationships between renal function variations and relative changes in cardiac troponin T concentrations based on quantile generalized additive models (qgam)
Diabetes
Association of hemoglobin H (HbH) disease with hemoglobin A1c and glycated albumin in diabetic and non-diabetic patients
Comparative study of i-SENS glucometers in neonates using capillary blood samples
Infectious Diseases
Evaluation of four commercial, fully automated SARS-CoV-2 antibody tests suggests a revision of the Siemens SARS-CoV-2 IgG assay
Vitamin-D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients
Does mid-regional pro-adrenomedullin (MR-proADM) improve the sequential organ failure assessment-score (SOFA score) for mortality-prediction in patients with acute infections? Results of a prospective observational study
Letters to the Editors
Global FT4 immunoassay standardization. Response to: Kratzsch J et al. Global FT4 immunoassay standardization: an expert opinion review
Free-thyroxine standardization: waiting for Godot while well serving our patients today
Prevalence of SARS-CoV-2 antibodies in health care personnel of two acute care hospitals in Linz, Austria
Pediatric evaluation of clinical specificity and sensitivity of SARS-CoV-2 IgG and IgM serology assays
Prevention and control of COVID-19 in the penitentiary of Florence
Pooling for SARS-CoV-2-testing: comparison of three commercially available RT-qPCR kits in an experimental approach
Very high SARS-CoV-2 load at the emergency department presentation strongly predicts the risk of admission to the intensive care unit and death
Next-generation sequencing and RT-PCR to identify a 32-day SARS-CoV-2 carrier
25-Hydroxyvitamin D concentrations in COVID-19 patients hospitalized in intensive care unit during the first wave and the second wave of the pandemic
Laboratory findings in a child with SARS-CoV-2 (COVID-19) multisystem inflammatory syndrome
Discrepant cardiac troponin results in a young woman
Response to: towards the rational utilization of SARS-CoV-2 serological tests in clinical practice
Congress Abstract
12th National Scientific Congress SPML,29–31 October 2020, Online, Portugal
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