Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter February 24, 2021

Prolymphocytic or Richter’s transformation of chronic lymphocytic leukemia?

  • Silvia Montolio Breva ORCID logo EMAIL logo , Rafael Sánchez Parrilla , Teresa Giménez Pérez and Carmen Araguás Arasanz

Corresponding author: Silvia Montolio Breva, PhD, Laboratori Clínic ICS Camp de Tarragona - Terres de l’Ebre – Hospital Universitari Joan XXIII, Av Dr. Mallafré Guasch, s/n, Edifici E, Planta-1, 43007, Tarragona, Spain, Phone: +34 699518333, E-mail:

Acknowledgments

We thank Dra. Carmen Araguás and Dra. Teresa Giménez from the Haematology department of Clinical Chemistry Laboratory, Joan XXIII University Hospital (Tarragona) for their support and technical assistance.

  1. Research funding: None declared.

  2. Author contributions: Silvia Montolio: conceptualization, analysis and interpretation of data, writing and review. Rafael Sánchez: conceptualization, analysis and interpretation of data, revision, supervision and final approval. Carmen Araguás: analysis and interpretation of data and revision. Teresa Giménez: analysis and interpretation of data, revision and supervision. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical approval: The research was in accordance with the Declaration of Helsinki and was approved by authors’ Institutional Review Board.

References

1. Dighiero, G, Hamblin, TJ. Chronic lymphocytic leukaemia. Lancet 2008;371:1017–29. https://doi.org/10.1016/s0140-6736(08)60456-0.Search in Google Scholar

2. Reiniger, L, Bödör, C, Bognár, A, Balogh, Z, Csomor, J, Szepesi, Á, et al.. Richter’s and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation. Leukemia 2006;20:1089–95. https://doi.org/10.1038/sj.leu.2404183.Search in Google Scholar

3. Wąsik-Szczepanek, E, Szymczyk, A, Szczepanek, D. Richter syndrome: a rare complication of chronic lymphocytic leukemia or small lymphocytic lymphoma. Adv Clin Exp Med 2018;27:1683–9. https://doi.org/10.17219/acem/75903.Search in Google Scholar

4. Jamroziak, K, Tadmor, T, Robak, T, Polliack, A. Richter syndrome in chronic lymphocytic leukemia: updates on biology, clinical features and therapy. Leuk Lymphoma 2015;56:1949–58. https://doi.org/10.3109/10428194.2014.979411.Search in Google Scholar

5. Woessner, S, Florenca, L. La citología óptica en el diagnóstico hematológico, 5th ed. España: Grupo Acción Médica, S.A.; 2006.Search in Google Scholar

6. Bennett, JM, Catovsky, D, Daniel, M-T, Flandrin, G, Galton, DAG, Gralnick, HR, et al.. Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. J Clin Pathol 1989;42:567–84. https://doi.org/10.1136/jcp.42.6.567.Search in Google Scholar

7. Rana, C, Sharma, S, Agarwal, M. Prolymphocytic and Richter’s transformation in peripheral blood: a case report and Review of literature. J Hematol 2014;3:86–8.10.14740/jh121wSearch in Google Scholar

8. Gorospe Sarasúaa, L, Jaureguízar-Oriol, A, Almonacids-Sánchez, C, Rioja-Martín, MA. Richter syndrome with extensive isolated pleural extranodal involvement: the importance of PET/CT imaging. Cartas científicas/Arch Bronconeumol 2017;53:641–52. https://doi.org/10.1016/j.arbr.2017.09.008.Search in Google Scholar

Received: 2020-12-08
Accepted: 2021-02-12
Published Online: 2021-02-24
Published in Print: 2021-07-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 26.4.2024 from https://www.degruyter.com/document/doi/10.1515/cclm-2020-1799/html
Scroll to top button