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Analysis of leptin-adiponectin ratio and C-reactive protein as potential biomarkers of metabolic syndrome in adolescents

  • Olaya de Dios , Claudia Vales-Villamarín , Leticia Herrero , Pilar Pérez-Segura , Leandro Soriano-Guillén and Carmen Garcés EMAIL logo

Corresponding author: Carmen Garcés, PhD, Lipid Research Laboratory, IIS-Fundación Jiménez Díaz, Avda. Reyes Católicos, 2, 28040 Madrid, Spain, Phone: +34 91 5504892, E-mail:

Funding source: Fondo de Investigación Sanitaria

Award Identifier / Grant number: PI 18/01016

Award Identifier / Grant number: PI 14/00344

Funding source: FEDER

Award Identifier / Grant number: RD09/0076/00101

Acknowledgments

The article is dedicated to the late Prof. Manuel de Oya as the warmest homage to his memory.

  1. Research funding: This research was funded by grants from the Fondo de Investigación Sanitaria (PI 18/01016 & PI 14/00344) and Biobank grant FEDER RD09/0076/00101. Olaya de Dios is a fellow of the Conchita Rábago Foundation. Claudia Vales-Villamarín is recipient of a research contract from Carlos III Institute of Health (pFIS).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study protocol was approved by the Ethics Committee of Clinical Investigation of the Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (PIC016-2019 FJD) and fulfills with Helsinki Declaration guidelines and Spanish legislation on clinical research in human subjects.

References

1. Weiss, R, Dziura, J, Burgert, TS, Tamborlane, WV, Taksali, SE, Yeckel, CW, et al.. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004;350:2362–74. https://doi.org/10.1056/nejmoa031049.Search in Google Scholar PubMed

2. Reddy, P, Lent-Schochet, D, Ramakrishnan, N, McLaughlin, M, Jialal, I. Metabolic syndrome is an inflammatory disorder: a conspiracy between adipose tissue and phagocytes. Clin Chim Acta 2019;496:35–44. https://doi.org/10.1016/j.cca.2019.06.019.Search in Google Scholar PubMed

3. Frühbeck, G, Catalán, V, Rodríguez, A, Gómez-Ambrosi, J. Adiponectin-leptin ratio: a promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk. Adipocyte 2018;7:57–62. https://doi.org/10.1080/21623945.2017.1402151.Search in Google Scholar PubMed PubMed Central

4. Frithioff-Bøjsøe, C, Lund, MAV, Lausten-Thomsen, U, Hedley, PL, Pedersen, O, Christiansen, M, et al.. Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity. Pediatr Diabetes 2020;21:194–202. https://doi.org/10.1111/pedi.12964.Search in Google Scholar PubMed

5. Graßmann, S, Wirsching, J, Eichelmann, F, Aleksandrova, K. Association between peripheral adipokines and inflammation markers: a systematic review and meta-analysis. Obesity 2017;25:1776–85. https://doi.org/10.1002/oby.21945.Search in Google Scholar PubMed

6. De Oya, I, Schoppen, S, Lasunción, MA, Lopez-Simon, L, Riestra, P, de Oya, M, et al.. Sex hormone-binding globulin levels and metabolic syndrome and its features in adolescents. Pediatr Diabetes 2010;11:188–94. https://doi.org/10.1111/j.1399-5448.2009.00559.x.Search in Google Scholar PubMed

7. Schoppen, S, Riestra, P, García-Anguita, A, López-Simón, L, Cano, B, de Oya, I, et al.. Leptin and adiponectin levels in pubertal children: relationship with anthropometric variables and body composition. Clin Chem Lab Med 2010;48:707–11. https://doi.org/10.1515/cclm.2010.142.Search in Google Scholar

8. Navarro, P, de Dios, O, Gavela-Pérez, T, Jois, A, Garcés, C, Soriano-Guillén, L. High-sensitivity C-reactive protein and leptin levels related to body mass index changes throughout childhood. J Pediatr 2016;178:178–82. https://doi.org/10.1016/j.jpeds.2016.08.020.Search in Google Scholar PubMed

9. Frühbeck, G, Catalán, V, Rodríguez, A, Ramírez, B, Becerril, S, Salvador, J, et al.. Involvement of the leptin-adiponectin axis in inflammation and oxidative stress in the metabolic syndrome. Sci Rep 2017;7:1–8. https://doi.org/10.1038/s41598-017-06997-0.Search in Google Scholar PubMed PubMed Central

10. Yuan, G, Jia, J, Di, L, Zhou, L, Dong, S, Ye, J, et al.. Effects of C-reactive protein on adipokines genes expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2012;424:462–8. https://doi.org/10.1016/j.bbrc.2012.06.133.Search in Google Scholar PubMed

Received: 2021-02-09
Accepted: 2021-04-21
Published Online: 2021-04-30
Published in Print: 2021-09-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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