Exciting work in the field of protein analysis and amino acid sequencing! This recent study explores ultra-short peptide detection using SiₓNᵧ nanopores fabricated via CDB. The team found that peptide aggregation and interactions are highly influenced by pore size and voltage conditions—key insights for improving nanopore-based sequencing methods. Despite challenges like noise and thickness limitations, the research opens up new avenues for peptide–pore interaction studies and biosensing technologies. The good news is, Norcada offers low-noise and ultra-low-noise chip options that can help the community with better results! Proud that Norcada’s NanoPores were part of this impactful research! #Nanopores #PeptideSequencing #Biosensing #SolidStateNanopores #Nanotechnology #MEMS #Nanoscience #Microanalysis #NanoporeResearch #NextGenSequencing #Biosensors #LabOnAChip #MaterialsScience #ProteinAnalysis #ScientificInnovation #ResearchCollaboration #YEGTech
Robert C. Womack Endowed Chair Professor of Engineering at Southern Methodist University
Unlocking Ultra-Short Peptide Detection with Solid-State Nanopores Detecting ultra-short peptides is a crucial step toward advancing protein analysis and amino acid sequencing. In our study, we fabricated SiₓNᵧ nanopores via CDB to explore peptide translocation under varying voltages and concentrations. Our findings reveal that peptides often exist in aggregated forms, with their interactions influenced by pore size and voltage conditions. Despite limitations such as noise and thickness constraints, this research highlights key insights into peptide–pore interactions and potential improvements for solid-state nanopore-based sequencing. Exciting prospects ahead for enhanced detection and deeper biological understanding! #Nanopores #PeptideSequencing #Biosensing