The potential role of chitin in allergic reactions

Trends Immunol. 2007 Oct;28(10):419-22. doi: 10.1016/j.it.2007.08.005. Epub 2007 Sep 7.

Abstract

Allergy, a potentially life-threatening condition, has at its heart an overly zealous T-helper type 2 response to environmental antigens. We are constantly flooded by potential allergens, both airborne and ingested. Although innocuous to some, common antigens can cause serious allergic reactions in susceptible individuals. Chitin, a polymerized sugar and fundamental component of arthropods and fungi, is not commonly deemed a potential allergen but can cause sensitization through frequent exposure. A recent intriguing study has highlighted the role of chitin in allergic reactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allergens / immunology*
  • Animals
  • Chitin / chemistry
  • Chitin / immunology*
  • Humans
  • Hypersensitivity / immunology*
  • Hypersensitivity / metabolism
  • Macrophage Activation
  • Th2 Cells / immunology

Substances

  • Allergens
  • Chitin