Funding source: Fonds Wetenschappelijk Onderzoek
Award Identifier / Grant number: 11F3121N
Award Identifier / Grant number: 11M2322N
Funding source: Bijzonder Onderzoeksfonds
Award Identifier / Grant number: 01D05220
Acknowledgments
The authors acknowledge Prof. Dr. Veronique Stove, Prof. Dr. Alain Verstraete, Dr. Matthijs Oyaert, Dr. Nathan Debunne, Taeyang Chin, the team of the core lab and toxicology department from Ghent University Hospital for their assistance with patient sample collection.
-
Research funding: S. Deprez and L. Boffel would like to thank the Research Foundation-Flanders (FWO) for granting them a PhD fellowship (application number: 11F3121N and 11M2322N). L. Heughebaert acknowledges the Special Research Fund (BOF) from Ghent University (application number: 01D05220) for granting her a PhD fellowship.
-
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
-
Competing interests: Authors state no conflict of interest.
-
Informed consent: Not applicable.
-
Ethical approval: The study was approved by Ghent University Hospital Ethics Committee (approval number EC BC-7241).
References
1. Oostendorp, M, El Amrani, M, Diemel, EC, Hekman, D, van Maarseveen, EM. Measurement of hematocrit in dried blood spots using near-infrared spectroscopy: robust, fast, and nondestructive. Clin Chem 2016;62:1534–6. https://doi.org/10.1373/clinchem.2016.263053.Search in Google Scholar PubMed
2. van de Velde, D, van der Graaf, JL, Boussaidi, M, Huisman, R, Hesselink, DA, Russcher, H, et al.. Development and validation of hematocrit level measurement in dried blood spots using near-infrared spectroscopy. Ther Drug Monit 2021;43:351–7. https://doi.org/10.1097/FTD.0000000000000834.Search in Google Scholar PubMed
3. Capiau, S, Wilk, LS, Aalders, MCG, Stove, CP. A novel, nondestructive, dried blood spot-based hematocrit prediction method using noncontact diffuse reflectance spectroscopy. Anal Chem 2016;88:6538–46. https://doi.org/10.1021/acs.analchem.6b01321.Search in Google Scholar PubMed
4. Capiau, S, Wilk, L, De Kesel, P, Aalders, M, Stove, C. Correction for the hematocrit bias in dried blood spot analysis using a nondestructive, single-wavelength reflectance-based hematocrit prediction method. Anal Chem 2018;90:1795–804. https://doi.org/10.1021/acs.analchem.7b03784.Search in Google Scholar PubMed
5. Delahaye, L, Heughebaert, L, Lühr, C, Lambrecht, S, Stove, CP. Near-infrared-based hematocrit prediction of dried blood spots: an in-depth evaluation. Clin Chim Acta 2021;523:239–46. https://doi.org/10.1016/j.cca.2021.10.002.Search in Google Scholar PubMed
6. Boffel, L, Heughebaert, L, Lambrecht, S, Luginbühl, M, Stove, CP. In-depth evaluation of automated non-contact reflectance-based hematocrit prediction of dried blood spots. Analyst 2022;147:5445–54. https://doi.org/10.1039/d2an01642g.Search in Google Scholar PubMed
7. Deprez, S, Stove, CP. Fully automated dried blood spot extraction coupled to liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring of immunosuppressants. J Chromatogr A 2021;1653:462430. https://doi.org/10.1016/j.chroma.2021.462430.Search in Google Scholar PubMed
8. Mayo Clinic Laboratories. Tacrolimus stability in EDTA whole blood [Internet]. 2021. Available from: https://www.mayocliniclabs.com/test-catalog/Specimen/35145 [Accessed 13 Feb 2021].Search in Google Scholar
9. Abu-Rabie, P, Spooner, N. Study to assess the effect of age of control human and animal blood on its suitability for use in quantitative bioanalytical DBS methods. Bioanalysis 2010;2:1373–84. https://doi.org/10.4155/bio.10.104.Search in Google Scholar PubMed
10. Deprez, S, Heughebaert, L, Boffel, L, Stove, CP. Application of non-contact hematocrit prediction technologies to overcome hematocrit effects on immunosuppressant quantification from dried blood spots. Talanta 2022;254:124111. https://doi.org/10.1016/j.talanta.2022.124111.Search in Google Scholar PubMed
11. Lange, T, Thomas, A, Walpurgis, K, Thevis, M. Fully automated dried blood spot sample preparation enables the detection of lower molecular mass peptide and non-peptide doping agents by means of LC-HRMS. Anal Bioanal Chem 2020;412:3765–77. https://doi.org/10.1007/s00216-020-02634-4.Search in Google Scholar PubMed PubMed Central
© 2022 Walter de Gruyter GmbH, Berlin/Boston
