Falsely low beta-hCG results in pregnant woman on Siemens Atellica: don’t forget the “hook effect”

Published by De Gruyter January 31, 2023

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Corresponding author: Adrien Nizet, Department of Laboratory Medicine, Clinique CHC MontLégia, Liège, Belgium, E-mail: Adrien.Nizet@chuliege.be

Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Not applicable.
Ethical approval: Not applicable.

References

1. Nodler, JL, Kim, KH, Alvarez, RD. Abnormally low hCG in a complete hydatidiform molar pregnancy: the hook effect. Gynecol Oncol Case Rep 2011;1:6–7. https://doi.org/10.1016/j.gynor.2011.10.003.Search in Google Scholar PubMed PubMed Central

2. Al-Mahdili, HA, Jones, GRD. High-dose hook effect in six automated human chorionic gonadotrophin assays. Ann Clin Biochem Int J Lab Med 2010;47:383–5.10.1258/acb.2010.090304Search in Google Scholar PubMed

3. Winder, AD, Mora, AS, Berry, E, Lurain, JR. The “hook effect” causing a negative pregnancy test in a patient with an advanced molar pregnancy. Gynecol Oncol Rep 2017;21:34–6.10.1016/j.gore.2017.06.008Search in Google Scholar PubMed PubMed Central

Received: 2022-11-25

Accepted: 2023-01-18

Published Online: 2023-01-31

Published in Print: 2023-06-27