Sexual exposures every time were associated with increased risks for transmission of infectious agents. In the different kinds of infectious hepatitis actual hepatitis B is sexual transmitted mainly. The most effective prevention is possible by immunization early in the lifetime. Hepatitis C very rarely is sexual transmitted. There is no strong correlation between viral load and risk of transmission by sexual contacts. Like in other infectious diseases including the HIV-infection only the use of condoms and avoiding of unprotected sexual intercourse is the most effective preventive measure.