Funding source: Onderzoeksraad, KU Leuven
Award Identifier / Grant number: C16/18/007
Funding source: Fonds Wetenschappelijk Onderzoek
Award Identifier / Grant number: G0B5120N
Funding source: Jeffrey Modell Foundation
Funding source: Agentschap voor Innovatie door Wetenschap en Technologie
Award Identifier / Grant number: ZL36300700
Acknowledgments
We would like to thank Anne Puel for critical evaluation of the data and discussions on the method and manuscript.
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Research ethics: The study was approved by the ethics committee of the University Hospitals Leuven (S52145, S50799 for control children, S63708 for control adults). The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).
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Informed consent: Informed consent was obtained from the patients or their parents, from the control children or their parents. Adult controls gave oral or written consent.
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Author contributions: The study was concepted and designed by Glynis Frans and Xavier Bossuyt. Material preparation, data collection and analysis were performed by Glynis Frans, Birthe Michiels, Louanne Ampofo, and Greet Wuyts. Collection of pediatric healthy controls was supervised by Jaan Toelen. Capucine Picard, Marc Raes, Jutte van der Werff ten Bosch, Rik Schrijvers and Isabelle Meyts supervised the clinical care of the included patients and provided the necessary clinical data. The data was critically reviewed and discussed with Jean-Laurent Casanova. The draft of the manuscript was written by Glynis Frans, Birthe Michiels, Louanne Ampofo, and Xavier Bossuyt. All authors commented on the first version and any version of the manuscript thereafter. All authors read and approved the final manuscript. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors state no conflict of interest.
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Research funding: This work was supported by a research grant from the Research Council of the Catholic University of Leuven C16/18/007 and a IWT-TBM grant (ZL36300700). IM is supported by the Jeffrey Modell Foundation. RS and IM are senior clinical investigators of the Fund for Scientific Research – Flanders. IM is supported by FWO G0B5120 N. IM and RS are members of the European Reference Network for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases -Project ID No 739543.
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Data availability: The raw data can be obtained on request from the corresponding author.
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Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/cclm-2023-0999).
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